Depends on what works better with the rest of your army. Vindicators work better with an aggressive army list, while Predators work better with a more gunline-oriented army. As The Mike Leon would tell you, Vindicators aren't as good in 5th because everyone and their mother gets a cover save now, but I'm still a fan.
I usually run a nice cheap 85-point Predator with autocannon and heavy bolters with my army. It usually makes its points back.